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- Higher Functioning Endogenous Opioid System Predicts Better Treatment Response For Neuropathic Pain Treated With Topical NSAIDs
- Half of veterans prescribed medical opioids continue to use them chronically
- Opioid regimens that deliver best pain control reflect assay findings of cytochrome defects
- Combined use of oxytocin and human chorionic gonadotropin in intractable pain patients
- Stem cell transplant shows 'landmark' promise for treatment of degenerative disc disease
- New study of proteins in space could yield better understanding, new drug development
- Establishing standards where none exist; researchers define 'good' stem cells
| Posted: 08 Mar 2014 06:52 AM PST Not only are neuropathic pain symptoms quite common in knee osteoarthritis, but scientists can predict who will respond to treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) by assessing the nervous system's own capacity to regulate pain, new research suggests. Patients whose tests had indicated superior conditioned pain modulation (CPM) had less pain and fewer neuropathic symptoms.  |
| Half of veterans prescribed medical opioids continue to use them chronically Posted: 08 Mar 2014 06:48 AM PST Of nearly 1 million veterans who receive opioids to treat painful conditions, more than half continue to consume opioids chronically or beyond 90 days, new research says. A number of factors were associated with opioid discontinuation with the goal of understanding how abuse problems take hold in returning veterans.  |
| Opioid regimens that deliver best pain control reflect assay findings of cytochrome defects Posted: 08 Mar 2014 06:48 AM PST Most patients with multiple defects of the cytochrome P450 system, which is largely responsible for metabolizing opioids, naturally gravitated toward an opioid regimen primarily metabolized through the cytochrome P450 3A4 enzyme or a non-cytochrome, metabolic pathway, a new study suggests.  |
| Combined use of oxytocin and human chorionic gonadotropin in intractable pain patients Posted: 08 Mar 2014 06:48 AM PST Two hormones credited with reducing pain and need for opioid analgesics when released naturally during pregnancy and childbirth worked similarly when administered simultaneously to patients with intractable pain, research shows.  |
| Stem cell transplant shows 'landmark' promise for treatment of degenerative disc disease Posted: 08 Mar 2014 06:48 AM PST Stem cell transplant was viable and effective in halting or reversing degenerative disc disease of the spine, a meta-analysis of animal studies showed, in a development expected to open up research in humans. Recent developments in stem cell research have made it possible to assess its effect on intervertebral disc (IVD) height, researchers reported.  |
| New study of proteins in space could yield better understanding, new drug development Posted: 07 Mar 2014 11:30 AM PST Innovative methods of drug discovery don't always take place in an academic laboratory. They may start there, but they can also happen in orbit aboard the International Space Station, as protein crystallization research is about to demonstrate once again.  |
| Establishing standards where none exist; researchers define 'good' stem cells Posted: 06 Mar 2014 10:04 AM PST A set of 64 crucial parameters has been identified by researchers from more than 1,000 by which to judge stem cell-derived cardiac myocytes, making it possible, for perhaps the first time, for scientists and pharmaceutical companies to quantitatively judge and compare the value of the countless commercially available lines of stem cells.  |
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