ScienceDaily: Health & Medicine News

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• Association between small-vessel disease, Alzheimer pathology studied
• Diets rich in antioxidant resveratrol fail to reduce deaths, heart disease or cancer
• Low rate of adverse events associated with male circumcision
• Underage college men discount dangers of driving after marijuana use
• Genetic blueprint for cancerous appendix tumors identified
• Hospitals ranked on complications after hip, knee replacement surgeries
• Mobilizing immune system against viruses: New way found
• Molecular motor for packaging virus DNA found, may lead to targeted antiviral drugs
• Alternative pathways let right and left communicate in early split brains
• Bullying may have long-term health consequences
• Second opinion changes woman's diagnosis from incurable to curable cancer: Case study
• Immune therapy might be effective for multiple myeloma
• Computer model helps Benin vaccinate more kids at lower cost
• Having a sense of purpose may add years to your life
• Pregnancy significantly increases risk of serious traffic crashes
• Scientists discover a natural molecule to treat type 2 diabetes: Molecule mimics some effect of physical exercise
• Link found between cell death, inflammatory disease
• Protein's role revealed in preventing heart muscle growth leading to heart failure
• Artificial magnetic bacteria 'turn' food into natural drugs
• Endocrine disruptors impair human sperm function, research finds
• ADHD Treatment Associated with Lower Smoking Rates
• Scientists slow brain tumor growth in mice
• Understanding Aspirin's effect on wound healing offers hope for treating chronic wounds
• New atlas of molecules paves way for improved understanding of metabolic diseases

Association between small-vessel disease, Alzheimer pathology studied Posted: 12 May 2014 06:41 PM PDT Cerebral small-vessel disease and Alzheimer disease pathology appear to be associated, new research indicates. "Our study supports the hypothesis that the pathways of SVD and AD pathology are interconnected. Small-vessel disease could provoke amyloid pathology while AD-associated cerebral amyloid pathology may lead to auxiliary vascular damage," researchers conclude.

Diets rich in antioxidant resveratrol fail to reduce deaths, heart disease or cancer Posted: 12 May 2014 06:41 PM PDT A study of Italians who consume a diet rich in resveratrol -- the compound found in red wine, dark chocolate and berries -- finds they live no longer than and are just as likely to develop cardiovascular disease or cancer as those who eat or drink smaller amounts of the antioxidant.

Low rate of adverse events associated with male circumcision Posted: 12 May 2014 06:40 PM PDT A low rate of adverse events was associated with male circumcision when the procedure was performed during the first year of life, but the risk was 10 to 20 times higher when boys were circumcised after infancy. "Given the current debate about whether male circumcision should be delayed from infancy to adulthood for autonomy reasons, our results are timely and can help physicians counsel parents about circumcising their sons," the researchers concluded.

Underage college men discount dangers of driving after marijuana use Posted: 12 May 2014 06:40 PM PDT The researchers say their findings probably reflect the widespread myth that driving after marijuana use is safe. The researchers suggest that developing strategies to combat this belief could help to change social norms and encourage using a designated driver not only after alcohol use, but after a driver has used any risky substance. Results are not surprising, but this study quantifies the prevalence, which is useful in setting priorities for public health action.

Genetic blueprint for cancerous appendix tumors identified Posted: 12 May 2014 12:53 PM PDT Using next generation DNA sequencing, scientists have identified potentially actionable mutations in cancers of the appendix. When specific mutations for a cancer type are identified, patients can be treated with chemotherapy or other targeted agents that work on those mutations. Little is known about the molecular biology of two types of appendix tumors, low-grade appendiceal mucinous neoplasm (LAMN) and adenocarcinoma, but both can lead to pseudomyxoma peritonea (PMP), a critical condition in which cancerous cells grow uncontrollably along the wall of the abdomen and can crush digestive organs.

Hospitals ranked on complications after hip, knee replacement surgeries Posted: 12 May 2014 12:53 PM PDT With an aging population comes an increase in hip and knee joint replacement surgeries, totaling almost one million procedures per year in the United States. To provide better information on the outcomes of these surgeries, help inform patient choice, and improve the quality of the nation's hospitals, a team of researchers has developed a measure for hospitals based on the complications following their patients' hip and knee replacements.

Mobilizing immune system against viruses: New way found Posted: 12 May 2014 12:53 PM PDT An intricate chain reaction in the body's immune system has been found by researchers who have used the knowledge to develop a new treatment against harmful viruses. Viral pandemics, such as the coronavirus that caused the deadly SARS outbreak in 2002, have caused hundreds of deaths, yet effective anti-viral drugs are rare.

Molecular motor for packaging virus DNA found, may lead to targeted antiviral drugs Posted: 12 May 2014 12:50 PM PDT New light has been shed on a type of molecular motor used to package the DNA of a number of viruses, including herpes and the adenoviruses. Their findings could help in the development of more effective drugs and inspire the design of new and improved synthetic biomotors. Viruses are the enigma of the biological world -- despite having their own DNA and being able to adapt to their environment and evolve, they are not considered to be alive like cells. In order to reproduce and multiply -- a requirement of "life" -- a virus must invade a living cell, eject its DNA into that of the cell, and commandeer the cell's biological machinery.

Alternative pathways let right and left communicate in early split brains Posted: 12 May 2014 12:50 PM PDT Humans who lack the corpus callosum, a bundle of 200 million fibers that connect the left and right hemispheres of the brain, have long fascinated physicians, neuroscientists and other curious minds. Now, a group of researchers puts an end to the Sperry's paradox, which describes major differences between individuals born with reduced or absent brain connections and those who acquire this condition later in life.

Bullying may have long-term health consequences Posted: 12 May 2014 12:48 PM PDT Bullied children may experience chronic, systemic inflammation that persists into adulthood, while bullies may actually reap health benefits of increasing their social status through bullying, according to researchers.

Second opinion changes woman's diagnosis from incurable to curable cancer: Case study Posted: 12 May 2014 10:59 AM PDT The case of a woman diagnosed with advanced, incurable lung cancer has been reported, whose disease was in fact early stage, curable lung cancer with additional lung lesions due to a rare antibiotic side effect. When her primary lung tumor was surgically removed, and the antibiotic stopped, the 62-year-old woman recovered and may now be cured.

Immune therapy might be effective for multiple myeloma Posted: 12 May 2014 09:43 AM PDT Genetically modified immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014, new research finds. The researchers modified T lymphocytes to target a molecule called CS1, which is found on myeloma cells, and to kill the cells. The findings support testing the potential therapy in a clinical trial.

Computer model helps Benin vaccinate more kids at lower cost Posted: 12 May 2014 09:43 AM PDT A modeling software called HERMES has been used by researchers to help the Republic of Benin in West Africa determine how to bring more lifesaving vaccines to its children. Results from the HERMES model have helped the country enact some initial changes in their vaccine delivery system, which may lead to further changes nationwide.

Having a sense of purpose may add years to your life Posted: 12 May 2014 09:43 AM PDT Feeling that you have a sense of purpose in life may help you live longer, no matter what your age, according to new research. The research has clear implications for promoting positive aging and adult development, says the lead researcher.

Pregnancy significantly increases risk of serious traffic crashes Posted: 12 May 2014 09:43 AM PDT Pregnancy is associated with a significant risk of a serious car crash requiring emergency medical care during the second trimester, according to a new research. Traffic mishaps place mother and baby at risk of fetal death, chronic disability and complicated emergency medical care. Statistically, about 1 in 50 pregnant women will be involved in a motor vehicle crash at some point during pregnancy.

Scientists discover a natural molecule to treat type 2 diabetes: Molecule mimics some effect of physical exercise Posted: 12 May 2014 08:25 AM PDT Researchers have discovered a natural molecule that could be used to treat insulin resistance and type 2 diabetes. The molecule, a derivative of omega-3 fatty acids, mimics some of the effects of physical exercise on blood glucose regulation.

Link found between cell death, inflammatory disease Posted: 12 May 2014 07:19 AM PDT A recently discovered type of cell death called necroptosis could be the underlying cause of inflammatory disease, researchers have found. The research team discovered that a previously identified molecule involved in necroptosis, called RIPK1, was essential for survival by preventing uncontrolled inflammation. This finding could lead to future treatments for inflammatory diseases including Crohn's disease, rheumatoid arthritis and psoriasis.

Protein's role revealed in preventing heart muscle growth leading to heart failure Posted: 12 May 2014 07:19 AM PDT For the first time the protein Erbin has been shown to be an important brake that helps prevent pathological cardiac hypertrophy. Researchers showed that damage to this protein leads to excess growth of heart muscle, a decrease in function, and severe pathological growth of heart muscle. Their research has implications for breast cancer treatment, as Erbin interacts with the receptor Her2/ErBb2, which is overexpressed in approximately 30 percent of breast cancers.

Artificial magnetic bacteria 'turn' food into natural drugs Posted: 12 May 2014 07:14 AM PDT Scientists have successfully created magnetic bacteria that could be added to foodstuffs and could, after ingestion, help diagnose diseases of the digestive system like stomach cancer. These important findings constitute the first use of a food as a natural drug and aid in diagnosing an illness, anywhere in the world.

Endocrine disruptors impair human sperm function, research finds Posted: 12 May 2014 07:14 AM PDT A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that may have a negative impact on fertilization, according to new research. The work suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that hitherto has not been recognized.

ADHD Treatment Associated with Lower Smoking Rates Posted: 12 May 2014 07:13 AM PDT Treating attention deficit hyperactivity disorder (ADHD) with stimulant medication may reduce smoking risk, especially when medication is taken consistently, according to an analysis. ADHD is a common childhood disorder that can continue through adolescence and adulthood, and is characterized by hyperactivity, difficulty paying attention and impulsivity. It is most commonly treated with stimulant medication (such as Vyvanse or Concerta), as well as with behavior therapy or a combination of the two.

Scientists slow brain tumor growth in mice Posted: 12 May 2014 07:13 AM PDT Much like using dimmer switches to brighten or darken rooms, biochemists have identified a protein that can be used to slow down or speed up the growth of brain tumors in mice. Brain and other nervous system cancers are expected to claim 14,320 lives in the United States this year.

Understanding Aspirin's effect on wound healing offers hope for treating chronic wounds Posted: 12 May 2014 07:12 AM PDT Researchers describe how aspirin acts on key skin cells called keratinocytes to delay skin repair at wound sites. A better understanding of this process offers hope for the development of drugs to encourage wounds to heal. The public health impact of chronic wounds is significant, affecting 6.5 million people in the US alone. Chronic wounds, a common complication of diabetes, are an increasing healthcare burden due to the rising incidence rates for obesity and diabetes.

New atlas of molecules paves way for improved understanding of metabolic diseases Posted: 11 May 2014 01:54 PM PDT A comprehensive study of associations between genetic variation and human metabolism will improve our understanding of the molecular pathways underlying common complex diseases such as hypertension, cardiovascular disease and diabetes. Researchers have linked 145 genetic regions with more than 400 molecules involved in human metabolism.

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