ScienceDaily: Health & Medicine News

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• Proteins team up to turn on T cells
• New images of a calcium-shuttling molecule that has been linked to aggressive cancer
• Reopening avenues for attacking ALS
• Friendly competition and a financial incentive increases team exercise
• New control strategies needed for Zika, other unexpected mosquito-borne outbreaks
• Zika virus: Antibodies identified with therapeutic and diagnostic potential
• New blindness prevention methods in diabetic eye disease
• Four steps for validating stem cells
• Stem cell scientists discover genetic switch to increase supply of stem cells from cord blood
• Extracting the content of single living cells
• Novel compound has promise for treatment of Huntington's disease
• Antibodies in patients with rare disorder may have role preventing type 1 diabetes
• Anticancer drug discovery: Structures of KDM5 histone demethylase inhibitors

Proteins team up to turn on T cells Posted: 15 Jul 2016 03:19 PM PDT Scientists are learning how cells make the decision to become T cells.

New images of a calcium-shuttling molecule that has been linked to aggressive cancer Posted: 15 Jul 2016 02:13 PM PDT Scientists have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. The three-dimensional structure could help researchers develop novel therapies and diagnostic tools for diseases that are caused by a malfunction in calcium adsorption.

Reopening avenues for attacking ALS Posted: 15 Jul 2016 02:13 PM PDT Researchers have found evidence that bone marrow transplantation may one day be beneficial to a subset of amyotrophic lateral sclerosis.The data suggests the most common genetic mutation associated with ALS plays an important role in not only the nervous system, but also the blood and immune systems.

Friendly competition and a financial incentive increases team exercise Posted: 15 Jul 2016 10:01 AM PDT Would having your exercise performance compared to that of your peers motivate you do more? A new study suggests that it might. And adding a financial incentive would only sweeten the deal even more. Comparing performance to average peers (the 50th percentile), and offering financial incentives was the most effective method for increasing physical activity among teams of employees.

New control strategies needed for Zika, other unexpected mosquito-borne outbreaks Posted: 14 Jul 2016 12:14 PM PDT A recent spate of unexpected mosquito-borne disease outbreaks -- most recently the Zika virus, which has swept through parts of the Americas -- have highlighted the need to better understand the development and spread of little-known diseases and for new strategies to control them, a new review suggests.

Zika virus: Antibodies identified with therapeutic and diagnostic potential Posted: 14 Jul 2016 12:06 PM PDT A team of researchers has identified novel therapeutic monoclonal antibody candidates isolated from Zika-infected patients and new strategies for Zika virus diagnostics. A new article describes for the first time an in-depth analysis of the human antibody and T cell immune response to the Zika virus infection with important implications for differential diagnostics and for the development of vaccines and new treatments.

New blindness prevention methods in diabetic eye disease Posted: 14 Jul 2016 10:51 AM PDT Indiana University researchers have created a virtual tissue model of diabetes in the eye that shows precisely how a small protein that can both damage or grow blood vessels in the eye causes vision loss and blindness in people with diabetes. The study could also lead to better treatment for diabetic retinopathy, which currently requires multiple, invasive procedures that aren't always effective in the long term.

Four steps for validating stem cells Posted: 14 Jul 2016 10:50 AM PDT Scientists have developed a robust method for characterizing human embryonic stem cells and their potential for medical applications.

Stem cell scientists discover genetic switch to increase supply of stem cells from cord blood Posted: 14 Jul 2016 10:50 AM PDT International stem cell scientists have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer patients needing transplantation therapy to fight their disease.

Extracting the content of single living cells Posted: 14 Jul 2016 10:50 AM PDT Biologists are increasingly interested in the behavior of individual cells, rather than the one of an entire cell population. A new method could revolutionize single cell analysis. The technology uses the world's smallest syringe to sample the content of individual cells for molecular analyses.

Novel compound has promise for treatment of Huntington's disease Posted: 14 Jul 2016 10:50 AM PDT A multi-institutional study has identified a promising treatment strategy for Huntington's disease (HD). The novel compound appears to protect against neurodegeneration in cellular and animal models of HD by means of two separate mechanisms -- inhibiting the regulatory enzyme SIRT2 and activating the antioxidant pathway controlled by the NRF2 transcription factor.

Antibodies in patients with rare disorder may have role preventing type 1 diabetes Posted: 14 Jul 2016 10:50 AM PDT People with a rare autoimmune disorder produce autoimmune antibodies that appear to be linked to a reduced occurrence of type 1 diabetes, new research has found. The study suggests these antibodies could limit immune-related diseases and may have therapeutic potential.

Anticancer drug discovery: Structures of KDM5 histone demethylase inhibitors Posted: 14 Jul 2016 10:47 AM PDT When doctors hurl toxic death at cancer cells, often a few will survive and come back. A family of enzymes called KDM5 histone demethylases is emerging as important for this resilience, and drugs that inhibit KDM5 enzymes could be active in treating several types of cancer.

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