ScienceDaily: Health & Medicine News

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• How our bodies interact with our minds in response to fear and other emotions
• Higher mercury levels in humans associated with increased risk for diabetes
• Novel drug combination showed antitumor activity in patients with incurable BRCA-deficient cancers
• Intermittent treatment with vemurafenib may prevent lethal drug resistance in melanoma
• Widely used filtering material adds arsenic to beers
• Do cells in the blood, heart and lungs smell the food we eat?
• Reducing waste of food: A key element in feeding billions more people
• Device keeps human liver alive outside body
• New link between heart disease and red meat: New understanding of cardiovascular health benefits of vegan, vegetarian diets
• Final chapter to 60-year-old blood group mystery
• Brain's stress circuits undergo profound learning early in life, scientists find
• New separation process advances stem cell therapies
• Global burden of dengue is triple current estimates
• Different drug combinations work best for prevention versus treatment of colorectal tumors
• Current HPV vaccine may not help some women with immune problems
• Engineered T cells kill tumors but spare normal tissue in an animal model
• Finding genes for childhood obesity: Genome wide study identifies genetic variants associated with childhood obesity
• Retinoic acid gradient visualized for the first time in an embryo
• First tests of old patent medicine remedies from a museum collection
• Ready for debut: Fruit-juice-infused chocolate with 50 percent less fat
• Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control
• KDM1 may represent a new therapeutic target for glioma
• Novel serum biomarker bilirubin predicted lung cancer risk in smokers
• Fetal exposure to excessive stress hormones in the womb linked to adult mood disorders
• First trial to investigate magic mushrooms as a treatment for depression delayed by UK and EU regulations
• Flies model a potential sweet treatment for Parkinson's disease
• Flies reveal kidney stones in-the-making
• Two-step ovarian cancer immunotherapy made from patients' own tumor benefits three quarters of trial patients
• Targeted toxin active in platinum-resistant ovarian cancers
• Immunotherapy showed promising antileukemia activity in pediatric patients
• New type of experimental drug active in platinum-resistant ovarian cancers
• HER2-positive breast cancer: Biomarker analysis identified women most likely to benefit from T-DM1
• Black women had worse breast cancer mortality regardless of cancer subtype
• More accurate markers identified for detecting response to epigenetic drugs for myelodysplastic syndromes
• Screening blood samples for cancer-driving mutations more comprehensive than analyzing traditional tumor biopsy
• Comprehensive genomic analysis identified alterations in head and neck cancer that could lead to targeted therapy
• Treatments, not prevention, dominate diabetes research
• Motor skills research nets good news for middle-aged
• MRI measure of blood flow over atherosclerotic plaque may detect dangerous plaque

How our bodies interact with our minds in response to fear and other emotions Posted: 07 Apr 2013 06:15 PM PDT New research has shown that the way our minds react to and process emotions such as fear can vary according to what is happening in other parts of our bodies.

Higher mercury levels in humans associated with increased risk for diabetes Posted: 07 Apr 2013 06:15 PM PDT A new study found that higher levels of mercury exposure in young adults increased their risks for type 2 diabetes later in life by 65 percent.

Novel drug combination showed antitumor activity in patients with incurable BRCA-deficient cancers Posted: 07 Apr 2013 03:35 PM PDT When given sequentially, two orally available experimental drugs -- sapacitabine and seliciclib -- worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers, according to phase I data.

Intermittent treatment with vemurafenib may prevent lethal drug resistance in melanoma Posted: 07 Apr 2013 03:35 PM PDT Vemurafenib-resistant tumors in patients with melanoma showed reduced growth after cessation of treatment, and in animal models, drug resistance was prevented by intermittent treatment, according to new data.

Widely used filtering material adds arsenic to beers Posted: 07 Apr 2013 03:35 PM PDT The mystery of how arsenic levels in beer sold in Germany could be higher than in the water or other ingredients used to brew the beer has been solved, scientists say.

Do cells in the blood, heart and lungs smell the food we eat? Posted: 07 Apr 2013 03:35 PM PDT In a discovery suggesting that odors may have a far more important role in life than previously believed, scientists have found that heart, blood, lung and other cells in the body have the same receptors for sensing odors that exist in the nose. It opens the door to questions about whether the heart, for instance, "smells" that fresh-brewed cup of coffee or cinnamon bun.

Reducing waste of food: A key element in feeding billions more people Posted: 07 Apr 2013 03:35 PM PDT Families can be key players in a revolution needed to feed the world, and could save money by helping to cut food losses now occurring from field to fork to trash bin, an expert said. He described that often-invisible waste in food — 4 out of every 10 pounds produced in the United States alone — and the challenges of feeding a global population of 9 billion.

Device keeps human liver alive outside body Posted: 07 Apr 2013 12:01 PM PDT In a world first, a donated human liver has been 'kept alive' outside a human being and then successfully transplanted into a patient in need of a new liver.

New link between heart disease and red meat: New understanding of cardiovascular health benefits of vegan, vegetarian diets Posted: 07 Apr 2013 10:33 AM PDT A compound abundant in red meat and added as a supplement to popular energy drinks has been found to promote atherosclerosis -- or the hardening or clogging of the arteries.

Final chapter to 60-year-old blood group mystery Posted: 07 Apr 2013 10:33 AM PDT Researchers have solved a 60-year-old mystery by identifying a gene that can cause rejection, kidney failure and even death in some blood transfusion patients. In this study they identified the gene that underlies the Vel blood group and will lead to the development of more reliable blood tests and reduce the risk for transfusion patients who lack this blood group.

Brain's stress circuits undergo profound learning early in life, scientists find Posted: 07 Apr 2013 10:33 AM PDT Researchers have discovered that stress circuits in the brain undergo profound learning early in life. Using a number of cutting edge approaches, including optogenetics, scientists have shown stress circuits are capable of self-tuning following a single stress. These findings demonstrate that the brain uses stress experience during early life to prepare and optimize for subsequent challenges.

New separation process advances stem cell therapies Posted: 07 Apr 2013 10:33 AM PDT A new separation process that depends on an easily-distinguished physical difference in adhesive forces among cells could help expand production of stem cells generated through cell reprogramming. The separation process could also lead to improvements in the reprogramming technique itself and expand disease modeling.

Global burden of dengue is triple current estimates Posted: 07 Apr 2013 10:32 AM PDT The global burden of dengue infection is more than triple current estimates from the World Health Organization, according to a multinational study.

Different drug combinations work best for prevention versus treatment of colorectal tumors Posted: 07 Apr 2013 10:32 AM PDT Researchers have tested the effectiveness of two promising drugs in preventing and treating colorectal adenomas in mice. Scientists found that the effect of these drugs, which have already been approved by the Food and Drug Administration for the treatment of other conditions, depends on whether adenomas are present when drug treatment begins.

Current HPV vaccine may not help some women with immune problems Posted: 07 Apr 2013 10:32 AM PDT Women with HIV acquire cancer-causing forms of the human papillomavirus that are not included in the current HPV vaccines Gardasil and Cervarix, according to new research.

Engineered T cells kill tumors but spare normal tissue in an animal model Posted: 07 Apr 2013 10:32 AM PDT Researchers devised a next gen cancer immune approach in which the activation signal for T cells is physically dissociated from a second costimulatory signal for immune cells. The two CARs carry different antigen specificity -- mesothelin and a-folate receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.

Finding genes for childhood obesity: Genome wide study identifies genetic variants associated with childhood obesity Posted: 07 Apr 2013 10:31 AM PDT A new study has revealed promising targets for the development of new drugs against childhood obesity. Researchers have identified four genes newly associated with childhood obesity and an increased burden of rare genetic deletions and rearrangements in severely obese children. Gaining a better basic understanding of obesity will open new doors to clinically relevant research.

Retinoic acid gradient visualized for the first time in an embryo Posted: 07 Apr 2013 10:31 AM PDT In a ground-breaking study, researchers report a new technique that allows them to visualize the distribution of retinoic acid in a live zebrafish embryo, in real-time. This technique enabled them to observe two concentration gradients going in opposing directions along the head-to-tail axis of the embryo, thus providing long-awaited evidence that retinoic acid is a morphogen.

First tests of old patent medicine remedies from a museum collection Posted: 07 Apr 2013 10:29 AM PDT What was in Dr. F. G. Johnson's French Female Pills and other scientifically untested elixirs, nostrums and other quack cures that were the only medicines available to sick people during the 18th, 19th and early 20th centuries?

Ready for debut: Fruit-juice-infused chocolate with 50 percent less fat Posted: 07 Apr 2013 10:29 AM PDT Already renowned as a healthy treat when enjoyed in moderation, chocolate could become even more salubrious if manufacturers embraced new technology for making "fruit-juice-infused chocolate," a scientist says.

Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control Posted: 07 Apr 2013 10:29 AM PDT Researchers have challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful.

KDM1 may represent a new therapeutic target for glioma Posted: 07 Apr 2013 10:29 AM PDT Researchers have generated preclinical data demonstrating that the protein KDM1, which functions as a lysine demethylase, is a potential target for glioma treatment, according to new research.

Novel serum biomarker bilirubin predicted lung cancer risk in smokers Posted: 07 Apr 2013 10:29 AM PDT Smokers with low bilirubin levels were at increased risk for lung cancer incidence and mortality compared with those who had the highest bilirubin levels, making serum bilirubin a potential biomarker for lung cancer risk prediction.

Fetal exposure to excessive stress hormones in the womb linked to adult mood disorders Posted: 07 Apr 2013 06:08 AM PDT Exposure of the developing fetus to excessive levels of stress hormones in the womb can cause mood disorders in later life and now, for the first time, researchers have found a mechanism that may underpin this process.

First trial to investigate magic mushrooms as a treatment for depression delayed by UK and EU regulations Posted: 07 Apr 2013 06:08 AM PDT The world's first clinical trial to explore the use of the hallucinogenic ingredient in magic mushrooms to treat depression is being delayed due to the UK and EU rules on the use of illegal drugs in research.

Flies model a potential sweet treatment for Parkinson's disease Posted: 07 Apr 2013 06:07 AM PDT Researchers describe experiments that could lead to a new approach for treating Parkinson's disease using a common sweetener, mannitol.

Flies reveal kidney stones in-the-making Posted: 07 Apr 2013 06:07 AM PDT Kidney stones usually make their presence known suddenly, often sending a person to the hospital in excruciating pain. New research identifies an important role zinc plays in the disease process.

Two-step ovarian cancer immunotherapy made from patients' own tumor benefits three quarters of trial patients Posted: 07 Apr 2013 06:07 AM PDT As many as three quarters of advanced ovarian cancer patients appeared to respond to a new two-step immunotherapy approach -- including one patient who achieved complete remission -- according to new research.

Targeted toxin active in platinum-resistant ovarian cancers Posted: 07 Apr 2013 06:07 AM PDT Researchers have found that a novel antibody-guided drug achieves responses in platinum drug-resistant ovarian cancer.

Immunotherapy showed promising antileukemia activity in pediatric patients Posted: 07 Apr 2013 06:07 AM PDT Researchers using patients' own immune cells in an immunotherapy approach called "anti-CD19 chimeric antigen receptor (CAR) T-cell therapy," achieved responses in children whose acute lymphocytic leukemia (ALL) had returned after a bone marrow transplant, according to preliminary results.

New type of experimental drug active in platinum-resistant ovarian cancers Posted: 07 Apr 2013 06:06 AM PDT The antibody-drug conjugate DMUC5754A, a novel member of a relatively new class of drugs, showed activity in women with ovarian cancer, even those with hard-to-treat, platinum-resistant disease, in a phase I trial. Those women with the highest expression of the drug's target, MUC16, gained the most benefit from treatment, which may help researchers predict which patients will benefit from treatment.

HER2-positive breast cancer: Biomarker analysis identified women most likely to benefit from T-DM1 Posted: 07 Apr 2013 06:06 AM PDT For women with metastatic, HER2-positive breast cancer, the amount of HER2 on their tumor might determine how much they benefit from a drug called trastuzumab emtansine (T-DM1), according to data from a subanalysis of the phase III clinical trial that led the U.S. Food and Drug Administration to approve the drug on Feb. 22, 2013.

Black women had worse breast cancer mortality regardless of cancer subtype Posted: 07 Apr 2013 06:06 AM PDT Black women with breast cancer had significantly worse survival compared with other racial and ethnic groups across cancer subtypes, which suggests that the survival differences are not solely attributable to the fact that black women are more frequently diagnosed with less treatable breast cancer subtypes, according to new data.

More accurate markers identified for detecting response to epigenetic drugs for myelodysplastic syndromes Posted: 07 Apr 2013 06:06 AM PDT Researchers have identified and validated two DNA methylation markers that could help physicians to more accurately determine a patient's response to epigenetic drugs for treatment of myelodysplastic syndromes (MDS), new research suggests.

Screening blood samples for cancer-driving mutations more comprehensive than analyzing traditional tumor biopsy Posted: 07 Apr 2013 06:06 AM PDT Researchers using a tool called BEAMing technology, which can detect cancer-driving gene mutations in patients' blood samples, were able to identify oncogenic mutations associated with distinct responses to therapies used to treat patients with gastrointestinal stromal tumors (GIST), according to new research.

Comprehensive genomic analysis identified alterations in head and neck cancer that could lead to targeted therapy Posted: 07 Apr 2013 06:06 AM PDT Not all head and neck squamous cell carcinomas (HNSCCs) have the same pattern of genomic alterations, but those cancers with certain distinctive patterns could be amenable to specific targeted therapies, according to new research.

Treatments, not prevention, dominate diabetes research Posted: 05 Apr 2013 04:56 PM PDT Research for diabetes is far more focused on drug therapies than preventive measures, and tends to exclude children and older people who have much to gain from better disease management, according to a new study.

Motor skills research nets good news for middle-aged Posted: 05 Apr 2013 03:46 PM PDT People in their 20s don't have much on their middle-aged counterparts when it comes to some fine motor movements, researchers have found. In a simple finger-tapping exercise, study participants' speed declined only slightly with age until a marked drop in ability with participants in their mid-60s.

MRI measure of blood flow over atherosclerotic plaque may detect dangerous plaque Posted: 05 Apr 2013 10:49 AM PDT Researchers have shown that using magnetic resonance imaging to measure blood flow over atherosclerotic plaques could help identify plaques at risk for thrombosis.

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